Enye indlela amangqamuzana omdlavuza acasha ngayo esimisweni somzimba sokuzivikela ezifweni iwukwenza umgoqo omncane ongaphezulu obizwa ngokuthi i-glycocalyx. Ocwaningweni olusha, abacwaningi bahlole izinto ezibonakalayo zalesi sivimbelo ngesixazululo esingakaze sibonwe, bathola imininingwane engasiza ekuthuthukiseni ama-immunotherapies omdlavuza wamaselula njengamanje.
Amaseli omdlavuza ngokuvamile akha i-glycocalyx enamazinga aphezulu ama-cell surface mucins, okucatshangwa ukuthi asiza ukuvikela amangqamuzana omdlavuza ekuhlaselweni amangqamuzana omzimba. Kodwa-ke, ukuqonda ngokomzimba kwalesi sivimbelo kuhlala kulinganiselwe, ikakhulukazi mayelana ne-immunotherapy yomdlavuza wamaselula, okubandakanya ukukhipha amangqamuzana omzimba esigulini, ukuwashintsha ukuze afune futhi abhubhise umdlavuza, bese uwabuyisela emuva esigulini.
"Sithole ukuthi ukushintshwa kokuqina kwesithiyo kuncane njengama-nanometer ayi-10 kuthinta umsebenzi we-antitumor wamaseli ethu omzimba noma amaseli enziwe nge-immunotherapy," kusho uSangwu Park, umfundi othweswe iziqu elebhu kaMatthew Paszek eCornell University e-ISAB, eNew York. "Sisebenzise lolu lwazi ukuklama amangqamuzana omzimba angadlula ku-glycocalyx, futhi sithemba ukuthi le ndlela ingasetshenziswa ukuthuthukisa i-immunotherapy yesimanje." Ibhayoloji.
“Ilebhu yethu iqhamuke nesu elinamandla elibizwa nge-scanning angle interference microscopy (SAIM) ukukala i-nanosized glycocalyx yamangqamuzana omdlavuza,” kusho uPark. "Le ndlela yokuthwebula isivumele ukuthi siqonde ubudlelwano besakhiwo se-mucins ehlobene nomdlavuza kanye nezakhiwo ze-biophysical ze-glycocalyx."
Abacwaningi badale imodeli yeselula ukulawula ngokunembile ukuvezwa kwe-cell surface mucins ukulingisa i-glycocalyx yamaseli omdlavuza. Babe sebehlanganisa i-SAIM nendlela yofuzo ukuze iphenye ukuthi ukuminyana komhlaba, i-glycosylation, kanye nokuxhumanisa kwe-mucins ehlobene nomdlavuza kuthinta kanjani ukushuba kwe-nanoscale barrier. Baphinde bahlaziya ukuthi ukushuba kwe-glycocalyx kukuthinta kanjani ukumelana namaseli ukuhlasela amaseli omzimba.
Ucwaningo lukhombisa ukuthi ukushuba kwengqamuzana lomdlavuza i-glycocalyx kungenye yemingcele eyinhloko enquma ukubalekela amaseli omzimba, nokuthi amangqamuzana omzimba akhiwe asebenza kangcono uma i-glycocalyx izacile.
Ngokusekelwe kulolu lwazi, abacwaningi baye baklama amangqamuzana omzimba omzimba anama-enzyme akhethekile ebusweni bawo abavumela ukuthi banamathele futhi bahlanganyele ne-glycocalyx. Ukuhlola ezingeni lamaselula kubonise ukuthi la maseli omzimba ayakwazi ukunqoba izikhali ze-glycocalyx zamangqamuzana omdlavuza.
Abacwaningi babe sebehlela ukunquma ukuthi le miphumela ingaphindaphindwa yini elebhu futhi ekugcineni ibe sezivivinyweni zomtholampilo.
I-Sangwoo Park izokwethula lolu cwaningo (isifinyezo) phakathi neseshini ethi “Regulatory Glycosylation in the Spotlight” ngeSonto, March 26, 2-3 pm PT, Seattle Convention Center, room 608. Xhumana nethimba labezindaba ukuze uthole ulwazi olwengeziwe noma udlule mahhala ingqungquthela.
U-Nancy D. Lamontagne ungumbhali wesayensi kanye nomhleli we-Creative Science Writing e-Chapel Hill, North Carolina.
Faka ikheli lakho le-imeyili futhi sizokuthumelela izindatshana zakamuva, izingxoxo nokunye okwengeziwe maviki onke.
Ucwaningo olusha lwasePennsylvania lunikeza ukukhanya kokuthi amaprotheni akhethekile avula kanjani ama-complexes aqinile wezakhi zofuzo ukuze zisetshenziswe.
UMeyi uyiNyanga Yokuqwashisa Ngezifo zikaHuntington, ngakho ake sibhekisise ukuthi iyini nokuthi singaselapha kuphi.
Abacwaningi bePenn State bathole ukuthi i-receptor ligand ibophezela ku-transcription factor futhi ikhuthaza impilo yamathumbu.
Abacwaningi bakhombisa ukuthi okuphuma ku-phospholipid ekudleni kwaseNtshonalanga kunomthelela ekwandeni kwamazinga obuthi bebhaktheriya emathunjini, ukuvuvukala kwesistimu, nokwakheka kwama-atherosclerotic plaque.
Okubalulekile kokuhumusha "ibhakhodi". Ukususwa kweprotheyini entsha ezifweni zobuchopho. Ama-molecule abalulekile we-lipid droplet catabolism. Funda izindatshana zakamuva ngalezi zihloko.
Isikhathi sokuthumela: May-22-2023